Suplementación de magnesio como tratamiento para los trastornos del estado de ánimo y la ansiedad: Una revisión sistemáticaMagnesium plays a crucial role in various bodily functions, including the nervous system, such as neurotransmitter regulation and over 300 enzymatic reactions. Mental disorders, such as depression and anxiety, affect a significant portion of the global population.
The aim of this systematic review is to assess the effectiveness of magnesium supplementation in the treatment of mood and anxiety disorders. A search for studies was conducted in the PubMed database, and seven randomized controlled studies involving a total of 621 participants were selected.
The results suggest that magnesium supplementation may be associated with a reduction in symptoms of depression and anxiety compared to control groups or standard care. Some studies also indicated that the combination of magnesium with vitamin B6 may have a synergistic effect in symptom reduction.
However, there are some limitations in the included studies, such as sample size and variation in the psychopathological scales used for diagnosis. It is concluded that more rigorous studies are needed to better understand the effects of magnesium supplementation on depression and anxiety symptoms and its comparison with control groups.
Keywords:
magnesium; magnesium supplementation; depression; anxiety
Fuente: Diagrama de flujo según Page MJ et al. 2020
DASS-2 = Depression and Anxiety Scale, BDI-2 = Beck Depression Inventory II, HDRS = Hamilton Depression Rating Scale, HARS = Hamilton Anxiety Rating Scale, CGIS = Clinical Global Impressions-Severity, PCS = Pain Catastrophizing Scale, PSQI = The Pittsburgh Sleep Quality Index, PHQ-9 = Patient Health Questionnaire, GAD-7 = General Anxiety Disorder-7, HAM-D = Hamilton Depression Rating Scale.